About 12 results found for searched term "Physalin H" (0.324 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M39852 | Physalin H | Hedgehog |
| Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC50 value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC50 values of 5.7 and 6.8 μM, respectively. | ||
| M19195 | Physalin F | Apoptosis |
| Physalin F is a secosteroid with potent anti-inflammatory and immunomodulatory activities. Physalin F induces apoptosis of PBMC, decreasing the spontaneous proliferation and cytokine production caused by Human T-lymphotropic virus type 1 (HTLV-1) infection. | ||
| M19197 | Physalin L | NO Synthase |
| Physalin L inhibits LPS-induced NO production in macrophages with the average inhibitory rate of 70.97%. Anti-inflammatory activity. | ||
| M38845 | Physalin B | Apoptosis |
| Physalin B induces cell cycle arrest and triggers apoptosis in breast cancer cells through modulating p53-dependent apoptotic pathway. Physalin B inhibits the ubiquitin-proteasome pathway and induces incomplete autophagic response in human colon cancer cells in vitro. | ||
| M38846 | Physalin A | Apoptosis |
| Physalin A induces apoptosis associated with up-regulation of caspase-3 and caspase-8 expression. Physalin A induces autophagy, found to antagonize apoptosis in HT1080 cells. Physalin A has the potential for the research of cancer disease. | ||
| M38989 | Isophysalin A | NO Synthase |
| Isophysalin A is a physalin with alpha and beta unsaturated ketone components. Isophysalin A binds to GSH and targets multiple cysteine residues on IKKβ. Isophysalin A also inhibits inducible NO synthase (iNOS) and nitric oxide (NO) production, showing anti-inflammatory activity. | ||
| M38995 | Physalin O | NO Synthase |
| Physalin O is a physalin that can be isolated from Physalis angulata. Physalin O shows cytotoxicity to Hep G2 and MCF-7 cancer cells with IC50 values of 31.1 and 11.4 µM, respectively. Physalin O inhibits the production of nitric oxide (NO) and shows anti-inflammatory activities. | ||
| M39129 | Physalin C | Metabolite/Endogenous Metabolite |
| Physalin C is a natural product that can be found in physalis angulata. Physalin C shows cytotoxic activities against MCF-7 and HepG2 cells. | ||
| M40098 | Physalin D | Others |
| Physalin D is isolated from the aerial parts of Physalis angulate. Physalin D displays considerable cytotoxicity against several cancer cell lines, showing IC50 values in the range of d 0.28 to 2.43 microg/mL. Physalin D has the potential for the cancer disease. | ||
| M44736 | 4,7-Didehydroneophysalin B | Others |
| 4,7-Didehydroneophysalin B is a flavonoid with cholinesterase inhibiting activity. 4,7-Didehydroneophysalin B can be isolated and purified from the natural Physalis alkekengi L. var. franchetii (Mast.) Makino. | ||
| M44897 | Isophysalin G | Others |
| Isophysalin G is a steroid that inhibits NO production induced by Lipopolysaccharides in macrophages with an IC50 of 64.01 μM. | ||
| M44974 | Physalin G | Others |
| 6-Epiphysalin G is isolated from natural Physalis alkekengi var. francheti.. | ||
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